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A burning sensation In the feet and hands is a painful feeling of heat, prickling, or stinging, typically caused by peripheral neuropathy (nerve damage), metabolic imbalances, or nutritional deficiencies.Common CausesDiabetic Neuropathy: High blood sugar over time harms the tiny nerves and blood vessels in the hands and feet.Vitamin Deficiencies: A lack of B-complex vitamins, especially Vitamin B12, weakens and damages nerve function.Organ Dysfunction: Build-up of toxins from poorly working kidneys or the liver can irritate nerve endings.Other Medical Factors: Thyroid issues, chronic alcohol use, or side effects from certain medicines can also trigger this hot, painful feeling.