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Digestive system definition The digestive system is a group of connected organs—specifically the gastrointestinal tract, liver, pancreas, and gallbladder—that break down food into tiny nutrients for energy, growth, and repair.Key OrgansMouth: Chews food and uses saliva to start breaking down starches.Esophagus: Moves food down to the stomach using muscle pushes.Stomach: Mixes food with strong acids and juices to turn it into liquid.Small Intestine: Absorbs most of the vitamins, minerals, and nutrients.Large Intestine: Takes out water and turns leftover food into waste.